26.14 Red cell folate (categories 3)
Over detection limit <14900 vs ≥14900.
26.14.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 178.181094 | 1 | <0.0001 | *** |
| rcfolate_gp3 | 1.581702 | 1 | 0.2 | ns |
| GA_samp | 72.949708 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 41.6216409 | 1 | <0.0001 | *** |
| rcfolate_gp3 | 0.2280064 | 1 | 0.6 | ns |
| GA_samp | 1128.5376199 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 423.138396 | 1 | <0.0001 | *** |
| rcfolate_gp3 | 2.101071 | 1 | 0.1 | ns |
| GA_samp | 564.814742 | 1 | <0.0001 | *** |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp3 | 1 | Inf | 0.807 | 0.807 | 0.4 | ns |
| GA_samp | 1 | Inf | 0.589 | 0.589 | 0.4 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp3 | 1 | Inf | 0.947 | 0.947 | 0.3 | ns |
| GA_samp | 1 | Inf | 0.448 | 0.448 | 0.5 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp3 | 1 | Inf | 4.497 | 4.497 | 0.03 | * |
| GA_samp | 1 | Inf | 0.987 | 0.987 | 0.3 | ns |
26.14.2 Model summary
Ratio of Geometric means (95% CI)
| Var | Effect | P |
|---|---|---|
| (Intercept) | 14.79 (9.96, 21.95) | <0.0001 |
| rcfolate_gp3≥14900 | 1.07 (0.96, 1.19) | 0.21 |
| GA_samp | 1.15 (1.11, 1.19) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.99 (1.61, 2.45) | <0.0001 |
| rcfolate_gp3≥14900 | 0.99 (0.93, 1.05) | 0.63 |
| GA_samp | 1.35 (1.33, 1.37) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.05 (0.04, 0.06) | <0.0001 |
| rcfolate_gp3≥14900 | 0.94 (0.87, 1.02) | 0.15 |
| GA_samp | 1.35 (1.32, 1.39) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 8.31 (5.12, 13.46) | <0.0001 |
| rcfolate_gp3≥14900 | 1.06 (0.93, 1.22) | 0.37 |
| GA_samp | 1.02 (0.97, 1.06) | 0.44 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.77 (1.07, 2.92) | 0.03 |
| rcfolate_gp3≥14900 | 1.07 (0.93, 1.23) | 0.33 |
| GA_samp | 1.02 (0.97, 1.06) | 0.50 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 4.85 (4.43, 5.32) | <0.0001 |
| rcfolate_gp3≥14900 | 1.04 (1.00, 1.08) | 0.03 |
| GA_samp | 1.00 (0.99, 1.00) | 0.32 |
26.14.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
26.14.4 Estimated marginal means
| Outcome | rcfolate_gp3 | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| PRL (ng/ml) | <14900 | 72.355 | 6.142 | 71.241 | 61.089 | 85.700 |
| PRL (ng/ml) | ≥14900 | 77.551 | 6.690 | 75.947 | 65.309 | 92.088 |
| hPL (μg/ml) | <14900 | 62.766 | 2.027 | 66.301 | 58.847 | 66.946 |
| hPL (μg/ml) | ≥14900 | 61.863 | 2.073 | 76.512 | 57.870 | 66.131 |
| GH2 (ng/ml) | <14900 | 1.490 | 0.059 | 82.604 | 1.377 | 1.612 |
| GH2 (ng/ml) | ≥14900 | 1.401 | 0.058 | 97.719 | 1.290 | 1.522 |
| Insulin (uU/ml) | <14900 | 10.044 | 0.430 | Inf | 9.236 | 10.923 |
| Insulin (uU/ml) | ≥14900 | 10.679 | 0.565 | Inf | 9.628 | 11.845 |
| HOMA-IR | <14900 | 2.098 | 0.094 | Inf | 1.922 | 2.290 |
| HOMA-IR | ≥14900 | 2.250 | 0.126 | Inf | 2.016 | 2.511 |
| Glucose (mmol/L) | <14900 | 4.657 | 0.048 | Inf | 4.564 | 4.753 |
| Glucose (mmol/L) | ≥14900 | 4.844 | 0.074 | Inf | 4.700 | 4.992 |
26.14.6 Post-hoc comparisons
| Outcome | Contrast | Ratio of Geometric means (95% CI) | P-value |
|---|---|---|---|
| PRL (ng/ml) | ≥14900 / <14900 | 1.07 (0.96, 1.19) | 0.2 |
| hPL (μg/ml) | ≥14900 / <14900 | 0.99 (0.93, 1.05) | 0.6 |
| GH2 (ng/ml) | ≥14900 / <14900 | 0.94 (0.87, 1.02) | 0.1 |
| Insulin (uU/ml) | ≥14900 / <14900 | 1.06 (0.93, 1.22) | 0.4 |
| HOMA-IR | ≥14900 / <14900 | 1.07 (0.93, 1.23) | 0.3 |
| Glucose (mmol/L) | ≥14900 / <14900 | 1.04 (1.00, 1.08) | 0.03 |